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Poly(ADP-ribose) polymerase-1 (PARP-1) cleavage in response to celastrol confirmed caspases-3 activation, albeit to a reduced extent relative to the prototypical ATP-competitive kinase inhibitor staurosporine (STS).
Synergism was observed, but to a reduced extent, in uvrA BC) and polA mutants, but was absent in exrA lexA), recA, recB, or recC mutants.
A surplus of offspring may potentially saturate the less attractive surrounding landscape but only to a reduced extent limited by its carrying capacity.
On the other hand, the Drosophila ortholog eag is also known to induce an increase in cell proliferation independently of ion influx [13], and a non-conducting KV10.1 point mutant still promotes tumor progression, although to a reduced extent [11].
For instance, by evaluating the PCNA+ve nuclei at each crypt cell position it became evident that proliferation could be maintained, but to a reduced extent.
Autosomal pairing centers behave differently; ZIM-1, ZIM-2 and ZIM-3 foci are only found at the autosomal pairing centers during leptotene/zygotene (and to a reduced extent in early pachytene) stage.
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Thus, the interfacial association and structure that are seen in DPC micelles persists in lipid bilayers, although to a greatly reduced extent.
In particular, there was no evidence for an up-regulation of respiration or KAR2 and PDI1 gene expression, and the genes associated with the ER, Golgi and protein degradation were generally induced only to a markedly reduced extent.
Behaviorally, the data showed that the mice explored the objects in the familiar location to a significantly reduced extent during reexposure (63.81 ± 6.97%; t-test, P < 0.0001; n = 16) when compared with novelty exploration (Fig. 5 c ).
This alliance will reinforce each nation's soft power with the other, and to an extent, reduce soft power imposed by the West.
There was, however, significant activation of contralateral V5/MT+ (Fig. 2D), albeit to a considerably reduced spatial extent and percentage signal change compared to the sighted hemifield.
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