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The Pidd (p53-induced protein with death domain) gene was shown to be induced by the tumour suppressor p53 and to mediate p53-dependent apoptosis in mouse and human cells, through interactions with components of both the mitochondrial and the death receptor signalling pathways.
Human studies include transfection of human cell lines with HLA-B27 and investigation of a possible interaction with pathogenic arthritis-related bacteria through changes in cytokine profiles, T-cell responses or HLA-B27 expression.
Datta, S. K. Major peptide autoepitopes for nucleosome-centered T and B cell interaction in human and murine lupus.
This lead to concerns about their interaction with human cells.
Verdegaal, E. M. et al. Neoantigen landscape dynamics during human melanoma-T cell interactions.
Their interactions with human cells are illuminating how cells regulate their own gene expression via RNA.
These results demonstrate the utility of screens in haploid cells to study interactions of human cells with bacteria.
"People learn to connect with other people through human interaction.
Personally connecting through human interaction accelerates relationship-building.
Command-initiated IEDs are detonated through human interaction with the triggering mechanism.
Sadly, eight to 10percentnt of the animals that end up here are injured through human interaction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com