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Thorough methodological quality assessment revealed that incomplete ascertainment of HAI status and/or lack of blinding of assessors occurred in one-third of studies, thus introducing a risk of bias and complicating a balanced interpretation of accuracy estimates.
To do so, however, a thorough methodological reflection is required which would reflect the genuine conceptual challenges, which arise from such an endeavor.
Several studies have investigated different phases of the GDSE process life cycle, but they do not offer systematic, comprehensive, and thorough methodological research specific to this topic.
Here we provide a thorough methodological description of a robust protocol to measure drug-induced cerebral blood volume changes in anaesthetised rats and mice.
It had a thorough methodological approach.
Data extraction and thorough methodological quality assessment was undertaken by two reviewers independently.
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This also needs to include a thorough discussion of methodological differences, e.g. the use of multi-variate rather than uni-variate statistical methods.
Given the word constraints inherent in the short abstracts, the assessment in the present study may not have provided a completely thorough representation of the methodological quality of the studies.
In order to obtain reliable data on leukocyte immunophenotyping for patient diagnostic purposes, we wanted to carry out a thorough evaluation on these methodological issues with a wide range of leukocyte surface antigens.
Although most reviews have concluded that psychosocial interventions are often efficacious in decreasing distress and improving QL, a more recent and thorough review using rigorous methodological criteria concluded that no strong recommendations and relatively few tentative recommendations could be made about the effectiveness of psychosocial interventions for cancer patients [ 39].
The purpose of this paper is to present a) guidelines concerning the development and implementation of a MRR based on a thorough literature review and b) methodological issues related to MRR within the context of a work-related traumatic brain injury (wrTBI) surveillance and prevention study involving MRR.
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