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I believe most or all instances of use of the word efficacy in this manuscript refers to a % reduction in the gametocyte density.
The definition for quality of life (QOL) that we use in this manuscript refers to an individual's "holistic" evaluation of satisfaction with his own life [ 7].
Double immunolabelling confirmed this observation; C1q and C3b co-localized with GFAP + reactive astrocytes within the plaque and peri-plaque (C3b in this manuscript refers to immunolabelling with the C3b/iC3b-specific monoclonal antibody C3/30).
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Technical specifications in this manuscript refer to the currently available PFDA model.
Further transformations including mean centering and quantile normalization were explored, but all data reported in this manuscript refer to the raw beta values deposited at GEO. Regrettably, each of the three samples for each individual were processed on the same chip, so there is confounding of individual with chip, as documented in the experimental design file Additional file 1: Table S2.
For example, the title of the manuscript refers to waves, but this is only observed in the wounding paradigm.
Local time (LT), wherever used in the manuscript, refers to Coordinated Universal Time (UTC) + 2; hence, no Daylight Saving Time was applied in summer.
Question 3: The manuscript refers to ?validation?
RESPONSE: Yes, the "deep parsing" in the manuscript refers to Stanford Dependencies.
DW chaired the consultation and NM, JK and ZE rapporteured the consultation to which the manuscript refers.
6) The manuscript refers to eIF2 phosphorylation and translational control, as highlighted in the title, but there were no experiments establishing cause/effect between eIF2 phosphorylation and the translation expression of a gene.
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