Exact(9)
This essentiality is linked to marked accumulations of fumarate resulting in protein and metabolite succination, a covalent modification of cysteine thiol residues.
This essentiality is especially pertinent to free-living microbes, where a species must be able to subsist within a range of environmental fluctuations.
This essentiality of the MYST pathway in plants is consistent with data related to the functions of MYST proteins in other organisms [ 16].
This essentiality contrasts with the low level of retention of Dsl1p and Dsl3p subunits across the eukaryotes; Dsl3p is unique to yeast whilst the core heterotrimer (Dsl1p/Tip20p/Sec20p) was only recovered from Opisthokonta, Amoebozoa and Viridiplantae groups.
Therefore, whereas panthothenate is commonly thought to be essential, this essentiality is strain specific and absent in C. difficile strain 630.
All agree that the services performed by some public employees are in one way or another "essential" and that this "essentiality" is in some sense related to society's ability to tolerate strikes.
Similar(50)
However, inconsistent with this supposed essentiality, mutations introduced in this region had no major effects and compensatory mutations did not restore translation activity [ 35].
This alleviated the essentiality of the region and enabled nickase-directed remodeling.
To further confirm this potential essentiality enrichment we downloaded the set of essential genes identified from experiments in the OGEE resource (see Methods).
We compared the results of this simulated essentiality screen with experimental gene essentiality results based on both narrow and broad gene essentiality criteria.
In [1] the author provided also the example showing the essentiality of this generalization.
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