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The smallest effective synthetic molecule was found to be an N-acetylmuramyl-l-alanyl-d-isoglutamine (MDP) [2, 3].
The smallest effective sample size was 170 as calculated by Tracer v1.4.1 (Rambaut and Drummond 2007) as five separate trace files or after serializing with LogCombiner (part of the BEAST package) indicating both an adequate burnin and convergence.
Having estimated s, we then calculated the smallest effective size required for the effect of negative selection to drive the mutation extinct (Nemin = 10/2s) and compared this with what it is known about the effective size of human populations to determine whether selection is strong enough to overcome the effect of genetic drift.
Most doctors choose to dose patients with only the smallest effective levels of information.
It is clearly in the interests of both nations that China maintain the smallest effective nuclear deterrent possible.
InSb has the smallest effective mass, the narrowest bandgap, and the highest intrinsic electron mobility of III-V semiconductors.
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To minimize the deleterious effects of inbreeding, especially in the small effective population sizes of zoo populations, managers of captive breeding programs preferentially breed individuals with the fewest close kin in the population.
Relatively low levels of mtDNA variation can result from range expansions, where the smaller effective population size of mtDNA genes can enhances founder effects.
Selection could have fixed some of these variants in some breeds or alternatively, given the small effective population size of breeds, strong genetic drift and founder effect might have overcome the possible negative effects of CNVs.
This is because the small effective population sizes (Ne < 10) of most mammal species mean that the effect of genetic drift is likely to overwhelm the small selection coefficients that distinguish most synonymous codons (1/ 2Ne) > s) [ 4, 15].
Moreover, the carrier mobility is enhanced with the decrease of radial length, in accord with the smaller effective mass of hole and electron for both types NTs.
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