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The SIGNIFY trial is testing the hypothesis that heart rate reduction using ivabradine reduces mortality and cardiovascular events in patients with stable CAD, but without clinical heart failure.
The SIGNIFY (Study assessInG the morbidity mortality beNefits of the If inhibitor ivabradine in patients with coronarY artery disease) trial includes patients with stable CAD and an LVEF above 40%%, with no clinical sign of HF, and is investigating the long-term effects (over a period of 48 months) of ivabradine in a large study population.
The SIGNIFY (Study assessInG the morbidity mortality beNefits of the If inhibitor ivabradine in patients with coronarY artery disease) trial includes patients with stable CAD and an LVEF above 40%%, with no clinical sign of HF, and is investigating the long-term effects (over a period of 48 months) of ivabradine in a large study population [ 76].
However, in the SIGNIFY trial a therapeutic regimen that is not approved for clinical use was applied, which included a higher initiation and uptitration dose (7.5 and 10 mg bid, respectively).
Similar(56)
The wine is our signifier, of course, and the signified is a hopeless bourgeois ideal.
So the signifying continues.
Using other biblical passages and patristic sources, he defended the "signifies" interpretation.
He first mentioned the "signifies" interpretation in a letter to Matthäus Alber, an associate of Luther.
The results signify the great potential of the studied materials for various advanced applications.
The forms signify the bodies of massacred American Indians.
Those pleas at the end signify the total helplessness of erotic life.
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