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This project will perform research to better understand AF and determine if abnormal activity in small regions or more widespread regions of the heart cause AF.
Since cardiac tissue has a limited regenerative capacity, any insults against the heart cause an irreversible myocardial damage dependent upon nature and magnitude of the insult, consequently inducing acute and/or chronic cardiac failure.
It seems highly unlikely that abnormalities in cell migration into or within the heart cause the defects, as Scrib f/f;Wnt1-Cre and Scrib f/f Isl1-Cre, in which Scrib is deleted in migratory NCC and second heart f/f Isl1-Cre respectinely, are phenotypically normal.
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Most disease-causing LMNA mutations affect the heart, causing a dilated cardiomyopathy, with or without skeletal muscle involvement.
The heart caused the most problems.
This suggests that there are specific effects on the heart causing the more dramatic increase.
Indigestion generates stomach gas which presses against the heart causing pain there.
In later stages of thyroid deficiency, fluid may accumulate around the heart, causing a condition known as pericardial effusion.
Extra stress in other areas of the heart, caused by the failed region, can lead to heart failure or the widespread death of heart cells.
She has chronic venous insufficiency, in which the leg veins struggle to return blood to the heart, causing terrible pain.
Unhealthy foods are often laden with cholesterol, which can build up in arteries and slow down the flow of blood to the heart, causing a heart attack.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com