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The phrase "The great difference" is correct and usable in written English.
It can be used to highlight a significant distinction or contrast between two or more things. Example: "The great difference between the two proposals lies in their approach to sustainability."
Exact(60)
The great difference — the great difference — is that I intend to win it first".
The great difference, of course, is that they ran things, and he did not.
The great difference in speed suggested to two investigators that the two movements are executed by different muscle fibres.
"The great difference between our Western Christian world and the atheistic Communist world is not political it is moral," McCarthy said.
The great difference between parascientific thought on one hand and religion and traditional philosophy on the other is perhaps encapsulated in that word "solve", assuming the use of the word is not simply a casual imprecision.
The great difference in the surface morphology was observed.
'The great difference in the tombs tell us that it was a stratified society.
The great difference between the numerical results obtained in the first and in the second approach is emphasized.
The great difference in binding mode between PA and the iron substrate makes PA act as either a corrosion inhibitor or a film former under different conditions.
The great difference now is the iPhone (or smartphone).
The great difference between the incidence of these cancers and mortality reflects enhanced patient survival.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com