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Moreover, we used the fitness quantitative data of Steinmetz et al. (2002) to calculate the essentiality for each gene.
As with our other tuberculosis-focused research, and computational approaches to repositioning compounds we embrace the essentiality for computational predictions to be interrogated through rigorous experimental studies.
Finally, in-frame exons 24 and 30 encode the FerB and Dysf-C2 domains, the additional domains for which the essentiality for dysferlin function is still unknown.
The tight link between dysregulated A-to-I editing and diseases highlights the essentiality for a balanced regulation and regulators responsible for maintaining the balance are promising therapeutic targets.
Similar(56)
By comparing the reconstructed GEMs of both Pichia species with S. cerevisiae, we found that the maximum capacities for the production of the 20 amino acids and the essentiality of reactions for the three yeasts to grow on glucose are similar (Additional file 4).
The essentiality of silicon for mammals, and humans in particular, remains questionable[4], and there is therefore no current recommended daily allowance.
Despite the essentiality of LuxS for AI-2 production, it has been claimed that Pfs, the upstream enzyme in this pathway, is rate-limiting for AI-2 production in E. coli [20].
Taken together, these data suggest the essentiality of PfI2 for the survival of blood stage parasites.
The essentiality of zinc for normal brain development is well established.
To confirm the essentiality of S158 for NobA activity, this residue was further mutated into an alanine.
Recent data, however, casts some doubt on the essentiality of SREBP1 for regulation of rodent adipocyte lipogenic gene expression [ 34].
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