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The biggest effect we've had is to get all the Italian-American organizations to work together".
The biggest effect of the Ukip surge could be in subsequent national elections.
The biggest effect was seen on the participants who were initially most anxious.
The biggest effect of the Microsoft case in Europe could prove to be on its many alliances and partnerships.
"The biggest effect is the weather.
The biggest effect is aesthetic.
The biggest effect will be on the coal industry with output down by about a fifth.
The biggest effect of eReaders may be that it enables the so-called "Long Tail" of publishing to flourish.
The biggest effect of last week's heat storm may be on next year's crop.
The biggest effect of this is to reduce false-positive SNP calls around indels, and accurately determine indel length.
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The impacts of a typical recession vary sharply across gender/race/ethnic groups, with the biggest effect among women.
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CEO of Professional Science Editing for Scientists @ prosciediting.com