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Croft et al. [42] also concluded that TPC is related to depression.
Our findings indicated that TPC is negatively correlated with PPT [41].
This study, therefore, examines the hypothesis that TPC would offer protection from ischemic brain damage in vivo.
Due to the different TPC between methanolic extract of T. ornata and ethanolic extract of S. polycystum (Table 1), it was suggested that TPC was not correlated well with DPPH radical scavenging activity.
In comparison with the first experiment (see Fig. 1), we expect a shift of the TPC due to the difference of duty cycles (factor of 10 between OPO1 and OPO2): indeed, the production of charge carriers by two-photon absorption only occurs when the pulse is illuminating the diode, so that TPC is actually dependant of the peak optical power.
However, studies from multiple laboratories reported that TPC overexpression promoted lysosomal Ca2+ release (Brailoiu et al., 2009; Calcraft et al., 2009; Pitt et al., 2010; Ruas et al., 2010; Grimm et al., 2017), suggesting that the relatively small Ca2+ permeability of TPCs is physiologically significant.
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We demonstrate that cytolytic granules are not only reservoirs of cytolytic proteins but are also the acidic Ca2+ stores mobilized by NAADP via TPC channels on the granules themselves, so that TPCs migrate to the immunological synapse upon CTL activation.
Our findings confirm TPCs as integral components of endogenous NAADP receptors, demonstrate that TPCs are both functionally and spatially diverse endolysosomal channels, and show that perturbation of TPC function and NAADP signaling might both underlie, and be used to ameliorate, disorders of endolysosomal trafficking.
Overall, the results indicate that TPC-FSM model has provided a better tool to capture extreme flows in the process of streamflow prediction.
In parallel studies we observed that TPC-1 cells express a strong mesenchymal phenotype, as evidenced by the expression of mesenchymal cytoskeletal proteins, such as vimentin, and the high deposition of extracellular matrix proteins, including collagens and fibronectin [40].
These claims are in line with previous findings by Wu et al. [ 27] who reported that TPC-rich extract of Laggera pterodonta exerts both hepatoprotective and antioxidant activities when assessed using the in vitro primary cultured neonatal rat hepatocytes.
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