Sentence examples for That sce from inspiring English sources

"The steam generator issues at SONGS also require that SCE be prudent with its future spending while SCE and regulators review the long-term viability of the nuclear plant," it said.

However, the observations that SCE but not GC is the most frequent HR occurring during replication stress suggest that SCE may be more critical for repairing PARP1 inhibition associated lesions.

We have found that SCE induced by DSBs following fork collapse is suppressed by ATR, whereas the frequency of SCE induced by replication fork stalling is similar in cells with or without ATR depletion [ 19].

SCEs were found to be distributed nonrandomly across fragile sites and nonfragile sites; and among the fragile sites, the high frequency SCE sites were highly correlated with the high frequency breakage sites [ 44], indicating that SCE are preferentially induced at common fragile sites with broken ends.

It was not until early 2015 that SCE learned additional information that indicated a report should be filed".

This suggests that Sce 33M2 is a strong loss-of-function or even a null mutation, consistent with the observation that Sce 33M2 mutants lack detectable Sce protein.

In support of the idea that SCE-associated HR is required for repairing the DNA lesions caused by PARP inhibitors, 53BP1 depletion restores the decreased frequency of SCE because of BRCA1 deficiency [ 84].

A caveat to these analyses is that SCEs and genomic rearrangements are more difficult to detect on chromosomes that have more than two copies within a cell, potentially limiting its use in highly polyploid cancer cells.

But, it should be also considered that SCEs, chromosome aberrations and point mutations are different endpoints of mutagenesis that may considerably vary for specific mutagens, and different primary lesions may be involved (Sonoda et al. 1999).

Furthermore, Rugo et al. (2011) found that naive mESCs exhibited a significant increase in the frequency of SCEs when they shared media with descendants of irradiated mESCs, and that SCEs were increased in cells that shared media with un-irradiated triple DNMT knockout mESCs, compared with cells that shared media with un-irradiated wild-type mESCs.

An in vitro binding assay revealed that 800CW-SCE, 680LT-SCE, and 750-SCE exhibited higher binding affinity than 2-PMPA, which is known as a PSMA inhibitor.