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Single-cell maps indicate that NL contacts involve multivalent interactions over hundreds of kilobases.
Experiment 1 showed that NL has particular difficulty discriminating sounds that differ in terms of rapid temporal changes, be they speech or non-speech sounds.
The results indicated that NL can be further applied in clinical examination and environmental detection, and the biomimetic designing can provide reference to the development of other fluorescent sensors.
Experiment 2 employed an intensive training program designed to improve rapid temporal processing in language impaired children (Fast ForWord Scientific Learning Corporationn, Oakland, CA) and found that NL was able to improve his ability to discriminate rapid temporal differences in non-speech sounds, but not in speech sounds.
Supporting this notion, Nelson and colleagues demonstrated that NL neurons co-cultured with TS16 mouse astrocytes exhibit reduced cholinergic function, while TS16 neurons co-cultured with WT mouse astrocytes display normal cholinergic activity [61].
Application of the same mapping technology at a higher resolution in human lung fibroblasts showed that NL interactions occur through large continuous genomic domains with sharply defined borders [8].
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The results show NL-NPs caused little reduction in cell viability compared with the control, but there was not any significant statistical difference between them, indicating that NL-NPs were better tolerated at the experiment's concentration.
In vivo analysis from knockout (KO) mice showed that NLs and Nrxs are essential for synaptic maturation and function (Varoqueaux et al., 2006; Missler et al., 2003; Chubykin et al., 2007).
This shows that NL-GS is both, reproducible, reliable and independent from the excitation beam aberrations.
Thus, it appears that NL-001/"Blue_13" was not introduced into the Netherlands as a single clone but as a set of several subclonal variants.
The isolates described in this study from 2004 on are the earliest reported for this genotype, which could indicate that NL-001/"Blue_13" originates from the Netherlands.
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