Sentence examples for That irf from inspiring English sources

Recently, the crystal structure analysis of IRF-1 and IRF-2 reveal that IRF DNA-binding domain consists of three α-helices, three long loops and four stranded anti-parallel β-sheets (Fig. 1) [21].

The finding that IRF may serve as an important regulator in lung lipid homeostasis merits further experimental validation.

It has previously been speculated that IRF family members may form a higher order transcriptional complex with Aire [ 30].

Recent studies demonstrated that IRF phosphorylation and subsequent proteasomal degradation are associated with induction of proliferation in normal breast epithelial cells (MCF10A).

One unexpected finding in these IRF siRNA knockdown experiments was that IRF-3 was not required for IFN induction.

Our observations indicated that IRF-3-mediated apoptosis of virus-infected cells could be an effective antiviral mechanism, without expression of the interferon-stimulated genes.

We show that IRF-1 down-regulates cyclin B1, cdc-2, cyclin E, E2F1, Cdk2, Cdk4, and results in p21-mediated G1 cell cycle arrest.

We show that IRF-7 siRNA knockdown enhanced LPS-induced IL-10 production in human monocyte-derived macrophages, and USP-18 overexpression attenuated LPS-induced production of IL-10 in RAW264.7 cells.

These data suggest that IRF-7C has an effect on IRF-4-knockdown-mediated growth inhibition.

A recent study demonstrated that IRF-5 is subject to TRAF6-mediated K63-linked ubiquitination [13].

These findings suggest that IRF-5P68 might negatively regulate IRF-5 transactivation activity.