Sentence examples for That chromatid from inspiring English sources

Other studies have examined MEFs from separase knock-out mice, finding that chromatid disjunction was blocked without separase, but again it was not determined whether chromosome arms or the centromeres were unable to separate [39], [40].

Taken together, these data indicated that chromatid separation did not occur in a regular fashion in MM and that this resulted in mitotic nondisjunction for at least some chromosomes.

The classical (and probably the prevailing current) view of radiation-induced chromosomal aberrations avers that chromatid breaks simply represent expansions of DNA double-strand breaks (DSB).

CO-FISH staining revealed that chromatid fusions in BRCA1- and CtIP-deficient MEFs involved both the leading and the lagging strand of the telomeres, with a slight bias towards lagging lagging fusions (Supplementary Fig S2D).

This quadratic dose response indicates that chromatid exchanges were produced by independent radiation-induced DSBs resulting from different tracks and that no interactions between radiation-induced DSBs and endogenous DSBs occurred in pluripotent cells.

PSSC in meiosis I is the most biologically plausible mechanism to explain this outcome and fits with the growing body of evidence that chromatid cohesion dysfunction is the primary contributor to age-related maternal meiotic errors.

These data suggest that chromatids produced by Scc1 cleavage in prometaphase zygotes are sufficient to trigger a stable mitotic arrest.

Together with the finding that chromatids trigger a delay in PBE that depends on Aurora activity, we conclude that the CPC can function in the absence of cohesin.

Our suggestion that Pcs1 (and Mde4) might be responsible for clamping together microtubule attachment sites on the same kinetochore raises another possibility, namely that chromatids are attached merotelically in the mutants.

Following replication, the resulting sister-kinetochores on each sister-chromatid ensure that one chromatid from each chromosome is transmitted to each daughter nucleus.

These results indicate that the chromatid axes from both sister chromatids are intimately associated at the LE.