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Yet, all subsequent research efforts failed to provide evidence of prognosis improvement by technique refinements of the primary treatment.
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Several high-volume centers have reported standardized techniques with refinements and subsequent outcomes.
The applicability and effectiveness of optimization techniques and refinements is highly dependent on the logic under consideration and on the class of problem being solved.
Thus, while nigral transplants clearly work well in select PD cases, the technique needs refinement before it can successfully be performed in a large series of patients.
It also represents an important step towards improving animal welfare and the three Rs' principles of humane experimental technique: replacement, refinement and reduction.
The lattice parameters were calculated using the unit cell refinement technique and the refined lattice constant values were compared with the standard JCPDF data source files.
But all of these techniques need refinement and improvement.
However, the techniques require refinement to allow rapid and online measurement of cytokines before the full benefit of such information can be effectively translated into better management of trauma patients.
To facilitate users and obtain the effective local refinement, this paper proposes a local refinement technique.
The XRD pattern was analyzed by refining the experimental data using a standard Rietveld refinement technique.
The structures were constructed using the program COOT40 and refined using the program REFMAC541,42 with the Translation Libration Screw refinement technique.
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