Therefore, it is highly desirable to create a means by which cancer cells could be targeted with high specificity and be simultaneously imaged in vivo [4].
Startups often struggle to find their customer base, but with digital, content marketing or digital campaigns, they can be targeted with extreme specificity to help find the exact audience the company needs". When a brand is able to create content with which their target audience identifies, it appeals to a psychological predilection towards engagement.
They should also target with high specificity to reduce off-target effects caused by blockade of non-pathogenic kinases.
Most of these peptides, are targeted with exquisite specificity to receptors, ion channels, and transporters in the nervous system [ 1- 4].
However, if DNA methylation can be targeted with high specificity to predetermined sites in the genome, DNA methylation-mediated gene silencing can be fully exploited as a research tool and further developed as a therapeutic approach.
Therefore, BT10 shows interaction with a restricted class of retinoid receptors and appears to target RARs with specificity.
Furthermore, high-throughput screens of nanoparticle libraries have identified nanoparticles that act as novel contrast agents and which can be targeted with enhanced diagnostic specificity and range.
Besides binding to the 5' untraslated region of a target mRNA with specificity achieved through base-paring between the two RNA molecules, sRNAs can also significantly down-regulate target protein levels, yet do not notably affect their target mRNA stability [11].
The inconvenience still rests with the targeting and the specificity efficiency.
Bacterial CRISPR Cas systems comprise diverse effector endonucleases with different targeting ranges, specificities and enzymatic properties, but many of them are inactive in mammalian cells and are thus precluded from genome-editing applications.
With governments at the national, state and local level targeting BP with surprising specificity and courts doing little to hold back the swelling lawsuit docket against the British oil giant, lawyers and executives at Shell may have taken another look at their legal reserves and their regulatory exposure to any problems in the Gulf.
