Findings from segregation analyses are often used to formulate tailored research hypotheses on the disease under investigation, and/or to decide on the type of investigative effort on the disease.
Such a screen could then reveal interesting localization patterns that are investigated in targeted follow-up experiments employing other markers tailored to the hypothesis inferred from the large-scale screen.
Chromatin bivalency poses an interesting hypothesis tailored to explain the molecular mechanisms involved in the regulation of accessibility and transcriptional competence of differentiation-specific genes in ES and adult stem and progenitor cells; however, several examples bypass the need for bivalency in pluripotent cells, such as epigenetic regulation of some loci during B-cell development.
Our proposed methodology for testing of non-target organisms is prescriptive with regard to the use of a procedure for selection of testing species and the development of proper testing protocols and risk hypotheses tailored to each case and receiving environment.
From the examples briefly presented above, reported and confirmed by the literature, the FTC appears to be suitable to identify real repurposing hypotheses tailored to a disease.
The issue of timing of exposure assessment may have to be tailored to specific hypotheses by examining exposure in cohorts of different ages.
Taking three Variant Call Format files as input, TrioVis allows the user to test different coverage thresholds (i.e. different levels of stringency), to find the optimal threshold values tailored to their hypotheses and to gain insights into the global effects of filtering through interaction.
Our findings do not confirm our hypothesis that our tailored implementation programme would improve GPs' role security, despite the efforts for tailoring to providers' baseline role security.
The modelling is tailored to the terminal decline hypothesis and effects of background variables such as gender and age are outside the scope of the present work.
The hypothesis that individually tailored e-mails would promote the uptake of MoodGYM, particularly among students expressing a current need for support, was not supported.
Primary hypothesis: The risk tailored intervention is more effective in reducing disability (functional disability and sick leave) compared to treatment as usual.
