Sentence examples for Systemic defect from inspiring English sources

Although its pathogenesis is complex, we have recently shown that CD patients have a systemic defect in macrophage function, which results in the defective clearance of bacteria from inflammatory sites.

Growth retardation may result from a systemic defect in hormonal regulation, DNA double-strand break repair, or other causal mechanisms.

To determine whether MGL1−/− mice had a systemic defect in innate activation, we examined the responsiveness of macrophages from MGL1−/− mice to proinflammatory stimuli.

A systemic defect in mitochondrial complex I is implicated in PD, and its pathological features have been reproduced by chronic exposure of mice to rotenone, a pesticide that specifically inhibits complex I [ 6].

Altogether, these data agree with the hypothesis that OC(D) joint specificity is due to the interaction of different molecular mechanisms, which are altered in all joints (systemic defect) but trigger a different susceptibility (joint specificity due to the different biomechanical constraints sustained by the joints).

I expanded this portion into suggesting that the systemic defect, such as glucocorticoid deficiency, can both make a seemingly promising drug to go further into clinical studies and subsequently rejected, as well as, more importantly, make an actually promising drug to fail in animal studies, and thus prevent it from crossing the translational divide.

In their view, Wukan's uprising highlighted systemic defects in China's local governments, and only a housecleaning — not an isolated slap on the wrist — will address them.

Severe anomalies of the penis are rare and are generally associated with urinary or other systemic defects that are incompatible with life.

"Councillor Lambert was saying that, in his opinion, the children are not properly protected, and that this lack of protection is a consequence of legislative and systemic defects".

WASHINGTON, July 15 (Reuters) - The World Bank has systemic defects in its procedures to ensure that people and the environment are not harmed in development projects, according to an internal review obtained by Reuters.

The first speaks to the glaring need for leadership development at all levels of an organization; the other to the reluctance to add full-time employees to payrolls for positions that may be better served by outside professionals - if they are empowered to provide their specialized skills without being absorbed into an organization's systemic defects.