Anyway preclinical studies and larger clinical trials have suggested additive or perhaps synergistic activity combining TMZ and RT [ 22].
Based on the preclinical data that shows synergistic activity for combining HSP90 inhibitors with taxanes, we are now conducting a phase I trial of ganetespib plus paclitaxel plus trastuzumab in trastuzumab refractory, HER2+ MBC (NCT02060253).
In addition, NO-donating aspirin demonstrated synergistic activity when combined with gold-containing compounds that are thought to primarily target the TR-Trx system [43].
Rapamycin has shown additive or synergistic activity when combined with other tyrosine kinase inhibitors such as Gleevec and PKC412 (Mohi et al, 2004).
But against S. aureus, silymarin and silibinin displayed substantial synergistic activity when combined with the antibiotics amikacin, reducing the MIC from 19.53 to 1.22 μg/mL (P < 0.001), gentamicin, lowering the MIC from 19.53 to 9.76 μg/mL (P < 0.001), and imipenem, reducing the MIC from 39.06 to 2.44 μg/mL (P < 0.001), compared to the control.
In addition, synergistic activities are seen when combining TNF with IL-17A or IL-17F.
On the basis of (i) the hypothesis that belinostat shows additive-to-synergistic activity when combined with commonly used cytototoxic agents including platinums (Pts) and taxanes and (ii) the lack of overlapping toxicity with these agents, this phase I study was designed to determine the MTD, DLT and the pharmacokinetic (PK) profile of belinostat, carboplatin and paclitaxel (BelCaP).
Synergistic activity of biNAbs was achieved by combining an engineered hinge domain of IgG3 to increase Fab domain flexibility necessary for hetero-bivalent binding to the Env trimer while retaining the functional properties of the IgG1-Fc.
In order to provide preliminary guidance for rational antibiotic combination therapy in the clinic, a systematic review and meta-analysis was performed to evaluate the in vitro synergistic activity of polymyxins combined with other antibiotics against Acinetobacter baumannii.
Then different concentrations of single agent or in parallel were used to further confirm the synergistic activity of the combined treatment through CCK8 assay.
As many traditional medicinal formulations are based on the combined and synergistic activities of several substances that enhance their pharmacological properties, investigations of the resulting mechanisms of action could help to uncover new medications for the treatment of diseases of the nervous system and mental illnesses.
