Sentence examples for Sustained application of from inspiring English sources
Sustained application of 10 nM epoxomicin recapitulated the selective loss of ErbB2 seen following POH1 knockdown, with minimal effect on EGFR levels (Figure 9A), whilst the extracellular domain antibody, Ab20, again showed a higher molecular weight smear upon proteasome inhibition (Figure 9B).
Many muscular dystrophies, including lethal Duchenne muscular dystrophy, are incurable and require the sustained application of drugs that have only minor treatment effects and serious negative side effects.
Mobilization typically involves a slow and sustained application of iatrogenic force, while manipulation is characterized by a rapid application of iatrogenic force.
Land having no significant limitations to sustained application of a given use, or only minor limitations that will not significantly reduce productivity or benefits and will not raise inputs above an acceptable level.
Recent studies demonstrated that sustained application of NMDA triggered cultured immortalized mouse podocytes produce ROS, associated with increased cell surface expression of p47phox and TRPC6 channels and reduced total and cell surface expression of podocyte slit diaphragm proteins nephrin and podocin without loss of cells [ 25].
5 This temporal separation between initial clinical suspicion and confirmation of infection routinely results in the early and sustained application of potent broad-spectrum antibiotics and antifungal agents aimed at covering the most likely pathogens as a 'safety first' strategy because a delay in appropriate antimicrobial therapy is associated with increased mortality.
We found that neither acute nor sustained applications of this drug disrupted the calcium sensitivity of TMEM16A channels.
The data presented is the result of sustained applications of substitution mapping for over a decade and constitutes the first report of a BP QTL within a very short congenic segment, containing variants within a single rat gene, Adamts16.
As a higher effective doxorubicin dose can be delivered locally compared with that delivered systemically, we speculate that the small amount of tumour remaining after resection, possibly containing doxorubicin-resistant cells, can be overcome by sustained local application of doxorubicin.
On the positive side, the new understanding of the city has generated an unprecedented interest in urban history and with it a proliferation of the detritus that usually results from the application of sustained study to a particular field.
Some master controller designs required application of sustained push force via spring-loading; that is, they were designed to fall back into the brake position if the driver were to let go (i.e. a "deadman" device).
