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The coordinated expression of the different genes in an organism is essential to sustain functionality under the random external perturbations to which the organism might be subjected.
To understand the neural origins of rhythmic behavior one must characterize the central pattern generator circuit and quantify the population size needed to sustain functionality.
Given the fact that several CEACAMs are GPI-anchored proteins or that they sustain functionality in the absence of a cytoplasmic domain, the mechanistic details of signal transduction processes initiated by these CEACAM family members are still widely unresolved.
To understand the cellular origins of these behaviors, key problems are to identify the rhythmogenic and premotor populations, and then quantify the requisite number of neurons to sustain functionality.
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Along this line, further long-term studies are needed to assess potential long-term pulmonary engraftment and sustained functionality of the transplanted iPSC-Mac.
Orthotopic implantations as pulmonary valve in sheep demonstrated sustained functionality up to 12 months, while the implant was gradually replaced by a layered collagen and elastic matrix in pace with cell-driven polymer resorption.
Current methods for ex vivo T cell expansion for adoptive T cell therapies are suboptimal, and achieving high T cell persistence and sustained functionality with limited systemic toxicity following transfer remains challenging.
Significant selective constraint on the sequences of these loci predicts that virtually all have sustained functionality across the Drosophila clade.
Under harsh conditions such as wide pH range (1 14), varied salt conditions (0.01 to 1 M), and a strong corrosive environment (1.0 M hydrochloric acid), quantum dots demonstrate extraordinary resiliency and sustained functionality [ 14]. Figure 8 shows the proliferation of human Mesenchymal Stem Cells (hMSC) that are labeled with quantum dots.
Even C initiates can go far with such object oriented approaches, because the general model of sustaining functionality is built into the very things you work with.
Thus, criticality is a property that can help us understand how the coordinate expression of the different genes in an organism is achieved under external perturbations, either to sustain cell functionality or to generate new phenotypes in order for the organisms to change and adapt to new environments [15] [21].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com