Women within the supplementary health network (those who used health plans) or those who paid the expenses of their own childbirth were considered to be part of the private sector.
The edges from the most differentially correlated hub sub-networks were then used as the classification features and each edge was quantified by the expression difference between the hub gene and interactor gene joined by the edge (Additional File 1 - Supplementary methods: Network-based feature selection methods focusing on sub-networks - Taylor's approach and BSS/WSS).
The full content of the first release of the CBN database is summarized in the Supplementary data, including network name, biological process, network description, version and network icon.
Twelve of the TASA genes (66.7%) were upregulated in response to TNF-α, as suggested by pathway analysis, but other cytokines, growth factors, and chemical compounds have also been shown to activate this network (Supplementary Fig. 21; Supplementary Data 5).
We found that the level of selective constraint of physically interacting proteins is more similar than expected from a random network (supplementary table S7, Supplementary Material online).
The ω-degree correlation is significantly higher for proteins in functional categories "signal transduction mechanisms" (P = 0.009) and "chromatin structure and dynamics" (P = 0.025) than for the rest of the network (supplementary table S2, Supplementary Material online).
This is also observed for the estimations obtained with BCA (fig. 6) and hybridization network (supplementary fig. S4, Supplementary Material online).
The star-shaped structure observed in the HBD network (supplementary figs. S2 and S3, Supplementary Material online) is in agreement with the atypical genetree of HBD built with our own resequencing data (CEU, PT, and YRI).
A performance study based on an instrumented mirror usingrsync + empirically characterizes server-side processing costs under realistic, large-scale workloads, and supplementary measurements of network throughput across Internet2 links illustrate the achievable network performance in a high-speed wide-area network.
