Genes with large epistatic effects interact strongly across the genome and tend to be involved in basic cellular function and maintenance (supplementary table S3, Supplementary Material online).
Only a subset of strains showed CRISPR/Cas bacteriophage resistance systems of different subtypes, suggesting a supplementary function in maintenance of chromosomal stability.
We first demonstrated that the infection procedure was compatible with stem cell maintenance (Supplementary Fig S3) and that on average thirty-five to forty-two per cent of the infected RDEB keratinocytes were positive for COLVII by immunostaining (Supplementary Fig S4).
Under these conditions, ALS8-iPSCs could be differentiated into motor neurons with similar efficiency as control-iPSCs, ∼5%, suggesting that P56S mutant VAPB does not inhibit motor neuron differentiation and maintenance (Supplementary Material, Fig. S4).
Supplementary Figure 1 MacroH2A1.2 function in telomere maintenance.
In the first trial, carp and tilapia were tested in single culture and in mixed culture with supplementary feeding at 2× maintenance level.
Micronutrients have also been supplementary used for the maintenance of growth process of all nature of crop.
They have circulated for a long time, interacting with maintenance and supplementary animal hosts.
During the registration period, strains of Leptospira species were isolated, from the animals (maintenance and supplementary hosts of the Leptospira), human patients, and environment, and saved in the Gamaleya Institute Microbial Collection (GIMC).
Supplementary Figure 2 G9a is dispensable for epidermal development and maintenance.
Remarkably, PARP14 is overexpressed in early stages of HCC and, importantly, its high expression is maintained during cancer progression, indicating that PARP14 upregulation might be required for both the formation and maintenance of HCC (Supplementary Fig. 1a).
