Supplementary advantage of ZI at the time of tumour resection is to give implants sufficient time to become osseointegrated before prospective radiotherapy course, then avoiding or minimizing its well-known negative impact on healing [23].
Apart from the watery distension medium, the supplementary advantage of the transvaginal approach is that it allows inspection of the tubo-ovarian organs in their natural position with easy exploration of the fossa ovarica without the need of manipulating instruments.
Furthermore, a supplementary advantage to encapsulation of organic dyes into silica beads is to enhance the detection limit by encapsulating a larger number of fluorophores molecules by synthesised probes.
Raman confocal microspectroscopy (RCMS) offers a supplementary advantage in zirconia transformation analysis.
A supplementary advantage of maximum parsimony is that it allows the identification of diagnostic events characterizing groups of cell lines.
In this case, the significant salutary effects of sildenafil and ecadotril per se entailed any supplementary advantage with combination treatment was negligible.
Importantly, this effect was shown not to be mediated by mtDNA replication stalling and subsequent replicative advantage (Supplementary Fig S3).
In the absence of cytokines, the Mcl-1 and BCL-2 transgenes provided comparable protection, but in the presence of cytotoxic agents, the BCL-2 transgene provided greater protection, consistent with previous observations, and co-expression of both conferred no additional advantage (Supplementary Figure 2).
Although others have tried to optimize drug combinations [ 24– 27], see Supplementary Methods, the advantage of our approach is that FSC is phenotypically driven, i.e., no mechanistic information is required in order to rapidly identify experimentally verifiable optimal drug combinations [ 22].
First, we observed that the heteroplasmy shift leading to dominance of wild-type mtDNA was accompanied by a considerable growth advantage (Supplementary Fig S6), so it was conceivable that the bulk population will over-represent cells with higher levels of wild-type mtDNA rather than demonstrate the true relationship between wild-type and CD mtDNA in individual cells.
It is therefore important to know the characteristic radiographic findings in arthritides in addition to the advantages of supplementary MRI and CT.
