ISE method suffers a drawback where it is necessary to perform calibration every hour in order to obtain a ±2% reproducibility.
Although the most reasonable approach in most situations, it suffers a drawback: replicating a ChIP-seq experiment will effectively reduce the number of peaks detected.
At present, these membranes suffer a relevant drawback: leaching of the free acid during fuel cell operation, which impedes their use below at least 150 °C.
Parametric methods generally suffer a major drawback, namely that their optimization algorithms often fail to converge to the optimal solution.
Although CD and FT-IR spectroscopy techniques are easy to perform and can accurately determine the secondary structure of amylin, these techniques suffer a major drawback when used as a screening technique for potential inhibitors of amylin-induced cytotoxicity.
BCS class III drugs suffer from a drawback of low permeability even though they have high aqueous solubility.
In contrast, without NC, an alternative is repeated broadcasting of user packets in a "data carousel" fashion, or managing the one-to-many automatic repeat request (ARQ) mechanism, which is known to suffer a number of drawbacks (e.g., excessive delay and the feedback implosion problem).
Although laser devices are commonly used to measure distances and vehicle speed in traffic safety-related studies, they suffer from a drawback known as the cosine effect.
The models of Silvescu et al., 2004 suffer from a drawback that for a large protein, the number of features their models need is prohibitively large, which is not the case for our model.
Millipede still suffers a big drawback of mechanical systems.
The most general kind of SPNs with product-form solution introduced by Coleman et al. (and denoted here by SΠ-nets) suffers a serious drawback: the existence of such a solution depends on the values of the transition rates.
