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Subtle defects in these tissues would not have been uncovered using the approaches employed here.
Subtle defects in the B cell compartment such as decreased proportions of memory B cells have also been reported [ 43].
Subtle defects in immunity [ 27] or idiopathic CD4 lymphopenia [ 28] could account for these variations, as could ethnic differences.
Subtle defects in TC-NER have been reported using similar HCR assays in other p53-deficient cells [ 41].
Subtle defects in cardiac structure and function can be detected before the presence of clinically evident cardiac disease [ 2, 3].
In incrosses of atp1a3a tpl10 heterozygotes we did not observe embryos with severely dilated (or otherwise morphologically defective) brain ventricles, but we have not assessed them for more subtle defects (Additional file 7: Figure S5A).
These images also reveal subtle defects.
Minor anomalies are subtle defects of appearance and structure evaluated subjectively or by measurement.
FOXP2 first came to light in a large London family, half of whose members had subtle defects in their speech and understanding.
Some diseases may consist of only extremely subtle defects in cells that render the cells more susceptible to injury in certain situations.
Applying finite-state verification techniques to software systems looks attractive because they are capable of detecting very subtle defects in the logic design of these systems.
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