There were also problems with its penetrative power; although the PIAT was theoretically able to penetrate approximately 100 mm of armour, field experience during the Allied invasion of Sicily, which was substantiated by trials conducted during 1944, confirmed otherwise.
No claims can be made that have not been substantiated by clinical trials.
However, this was neither statistically analysed nor substantiated by fertility trials.
Concerns regarding hypoglycemia, substantiated by such trials, have caused major medical oversight committees to recommend a less strict approach to glycemic control [ 8- 10].
Such a regulatory function would have important implications for B-cell depletion therapies, which so far have not been substantiated by clinical trials.
However, they pose new challenges to the regulatory system, requiring that the precise particularities of the application of drugs as mono-therapy, or in combination are well understood and substantiated with clinical trials data.
22 An additional interesting observation that needs to be substantiated in further trials is that the proportion of time involving stimulation in the aDBS mode tended to progressively fall as this mode was maintained.
Although nutritional support is a key component of conservative therapy in such cases, there have been no well-designed clinical trials substantiating the superiority of either total parenteral nutrition or enteral nutrition.
"The charges against them (the brothers) have not been substantiated during the trial," said EU spokeswoman Maja Kocijancic.
From therapeutic orientation to altruism: The " therapeutic orientation " of randomized controlled trials substantiates the tendency to justify patients' participation in randomized controlled trials based on the therapeutic benefits that they may derive from participating in such studies.
Furthermore, we extracted information on whether the authors mentioned any additional benefit beyond the NI claim of the drug and whether the additional benefit was substantiated in the trial via descriptions (e.g., via simple distribution tables) or formal statistical analyses.
