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We substantiate this point of view by the fact that the procedure of thinning the sample using FIB leads to some gallium contamination and surface amorphization of the gold, which (depending on the FIB conditions used) can influence up to tens of nanometres for each of the groove surfaces34,35.
To further substantiate this point, we studied the effect of dibromobimane (DBB, mass 350.01), a reagent known to cross-link cysteine residues within 3 6 Å distance [25].
Examples of national trends taken from a large collated, spatially explicit dataset [16, D. Sumilo 2006, DPhil thesis, Oxford University], to be published separately, substantiate this point (Fig. 8).
To further substantiate this point, we perform a series of permutations towards disease-disease, domain-disease, and domain-domain relationships.
To substantiate this point, Figure 3 highlights the high similarity of SF and orientation spectra of stimulus images before and after phase scrambling.
More work should be performed to substantiate this point by adding the following experiments: - Experiments in Figure 8 show that Atl contributes to S. aureus virulence but they do not show if this is linked to a higher activation of the Toll pathway.
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We thank the reviewer for this excellent suggestion, and believe that the revised paper is significantly improved by substantiating this point, which is a central to our work.
Further studies with microdialysis and transplantation of 5-HT neurons have substantiated this point, and the latter has shown that 5-HT input to the CPG of locomotion located at lumbar level in the rat was mandatory for locomotion.
To substantiate this view point, we furnish the following examples: Example 2.1.
12.01pm: Here's what Carol Day, WWF-UK's solicitor, had to say: The Red Tape Challenge suggests that the Habitats Directive Regulations were a 'burden on business', but when we asked Defra we were told that the review had no submissions to substantiate that point and found no evidence of delays to decision-making or gold-plating.
The SILAC data is presented in the current manuscript to substantiate the point that most proteins accumulate in the membrane in the absence of AP2, but GPI-linked proteins behave differently and therefore their sorting behaviour requires further study.
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