Sentence examples for Substantially impairs from inspiring English sources
In contrast, lentiviral down-regulation of GARP in human alloantigen-specific Treg cells by specific small interfering RNA (siRNA) substantially impairs suppressor function and FOXP3 expression that is associated with impaired induction of CD83 and CD27, both known to regulate FOXP3 [ 21, 32, 33].
In the Hinckley trial, Federal District Judge Barrington Parker instructed the jury to acquit Hinckley if they found his actions were related to "any abnormal condition of the mind, regardless of its medical label, which substantially affects mental or emotional processes and substantially impairs his behavior controls".
Formation of complexes containing two or more copies of pathogenic polyQ molecules substantially impairs cell viability.
Functionally, this is important because it substantially impairs utility of the extremity.
This mutation substantially impairs signalling activity, but retains the ability to interact with Fz4CRD and heparin.
Uremic pruritus (UP) is a significant complication in ESRD patients and substantially impairs their quality of life.
As fragility bone fracture may substantially impair quality of life, and also has substantial adverse socioeconomic consequences, our findings suggest that osteoporosis should be detected and addressed promptly in patients with bDMARD-treated RA who possess these risk factors.
The motion further contends that this irrelevant statement should be withheld from public dissemination because of the substantial risk that public disclosure will lead to widespread hostile publicity which would substantially impair the Defendant's fair trial rights, and would pose a serious threat to the administration of justice.
However in Australia, Grant Thornton said "the investment is likely to be substantially impaired".
His lawyer, Lynn Armentrout, argued, "The state doesn't have the power to undo or substantially impair a private contract".
The jury found that these symptoms had not substantially impaired his rational judgment.
