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"Substantial obstacles" is a correct and usable phrase in written English
You could use it when pointing out challenges that someone is likely to encounter in a certain task or situation. For example: "The project will involve substantial obstacles and will require a great deal of hard work."
Exact(54)
Substantial obstacles lie in the way.
Still, he faces substantial obstacles.
Ms. Bachmann would have substantial obstacles to overcome.
That may well be the case for Mr. McCain too, and he faces substantial obstacles.
But Pentagon officials have said there are substantial obstacles to any such sales.
"They may pull through," said Patrick Finnegan, a senior vice president at Moody's Investors Service, "but they face substantial obstacles".
Similar(6)
Third, effective dissemination is a substantial obstacle, and delivery is easily disrupted by environmental and meteorological conditions.
But the filmmakers' tendency to seek the same results with their living actors as they would with their puppets is also a substantial obstacle.
"Each places a substantial obstacle in the path of women seeking a previability abortion, each constitutes an undue burden on abortion access … and each violates the Federal Constitution".
In the early stages of pregnancy, the court barred only laws that are a "substantial obstacle to a woman seeking an abortion".
In her ruling on Casey, she changed the standard from "severe limitation" to "substantial obstacle".That, however, is a Supreme Court justice's prerogative.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com