Substantial modification of hepatic DNA occurred and persisted for a period of 2-4 weeks after a single exposure to BaP.
And there seemed to be something in him which took it for granted that anything said by anybody except himself needed immediate denial or at least substantial modification.
Automobile assembly plants did not readily accommodate airframes, nor could an automobile engine factory be converted without substantial modification.
The experts believe the Coalition's Direct Action policy needs substantial modification to reach the 2030 emissions reduction target that the government will pledge at the Paris climate change meeting next month.
Mr. Powell has already expressed skepticism about the rules and is in the middle of a review of them that experts predict will lead to their substantial modification in favor of the regional Bell companies.
And once the government commits to a target it will be under pressure to explain the policy it intends to use to meet it, with business groups, thinktanks and market analysts all arguing the Direct Action policy would need substantial modification before it was up to the task.
In the latter part of the 20th century and continuing into the 21st century, civil-law systems underwent substantial modification as a result of the changing sources of law in modern, bureaucratic, regulatory states.
The latter changes are now pervasive and range from the introduction of pesticides, such as DDT, and other industrial toxins, such as the PCBs, and acid rain, with substantial modification of the sulfur, nitrogen, and hydrogen ion budgets of ecosystems over large areas.
On the contrary, firms can modify commercial names with no substantial modification of the products.
Moreover, substantial modification was seen in the hydrophobicity and surface roughness.
The main substantial modification to the protocol was approved in October 2011, following DAA withdrawal from the market.
