Ubiquitous expression of a dominant negative Rab5 protein (Rab5 S43N;[53], [53]) using the e22-GAL4 didver did not cause substantial epithelial integrity defects, but did lead to defects in dorsal closure and head involution; cuticles had small dorsal holes and defective head skeletons (Fig. 3B).
Real estate, of the genre that's likely to multiply in lower Manhattan, represents a substantial investment against integrity.
In a statement the IAAF said these athletes would have to show they were "not tainted by the Russian Athletics Federation's failure to put in place adequate anti-doping systems because they have been subject to other, fully adequate systems outside of the country for a sufficiently long period to provide a substantial assurance of integrity".
As for the ground surface integrity, however, substantial improvements were realized.
The guidelines require investigators to provide notice unless it would "pose a substantial threat to the integrity of the investigation".
In various applications, welding-induced residual stresses have a substantial impact on the integrity of welded constructions.
"We must notify the media organization in advance unless doing so would pose a substantial threat to the integrity of the investigation," Mr. Machen's spokesman, William Miller, said.
The Washington, D.C., U.S. Attorney's office, in a statement, cited an exception: it was allowed to not to tell if giving such a warning "would pose a substantial threat to the integrity of the investigation".
Normally too, it would have had to notify the media in advance unless, as in this case, "doing so would pose a substantial threat to the integrity of the investigation".
For his part, McConnell, in a floor speech Monday, backed a "substantial investment in the integrity of our border" while also urging a "bipartisan agreement" to ensure government operations remain open beyond Friday.
"If there is what appears to be a very substantial question on the integrity of the election, clearly we would oppose Mr. Harris being seated until that is resolved," Hoyer said.
