Sentence examples for Substantial difficulties from inspiring English sources

Substantial difficulties due to nonidentical relative degrees and directed interaction graphs are surmounted in this result.

Substantial difficulties have to be overcome before the needs of practising engineers for dealing with uncertainties in decision making can be met fully by risk-based structural safety analyses.

Substantial difficulties emerge however at the delimitation of regions that are regarded as social constructs, the central category of which is the identity.

Substantial difficulties remain with performing WGS on bacterial samples on a routine basis or even just during outbreaks.

Substantial difficulties arise in epigenetic regulation, including with inhibition, due to the context-dependent nature of effects, linked, at least in higher organisms, to redundancy and adaptation.

"There are substantial difficulties in prosecuting cases committed in war zones," the official said.

Participants encountered substantial difficulties with the inflexibility of the diagnostic equipment.

The membrane itself may play a role but creates substantial difficulties for structural studies.

Established techniques such as thermal evaporation or sputtering have shown substantial difficulties in fully metallizing the prepared patterns.

Researchers and clinicians have experienced substantial difficulties locating measures that are suitable for use within palliative care settings.

Significant advantages are revealed when dealing with problems posing substantial difficulties in keeping diversity, including many-objective problems.