Sentence examples for Substantial alterations from inspiring English sources

Substantial alterations appear to have take place during the early years of Samuel Egerton's ownership in the mid-18th century.

Altogether, these disorders lead to substantial alterations of the intestinal microbiota and may alter and disturb the finely tuned intestinal hemostasis [10].

Meanwhile, substantial alterations were also observed in metabolites related to oxidative stress.

Both the Admiralty and the KM made substantial alterations to their organizations and doctrine in the process.

To be fair to Mr. Joffé, however, the movie has reportedly undergone substantial alterations since its filming in Moscow in 2005.

Syriza may secure a few minor tweaks to the pace and nature of the reform programme – but these won't be substantial alterations.

But after the scholars obtained a copy of a draft screenplay, criticized it severely and proposed substantial alterations, a fierce war of spin and counterspin broke out.

For instance, the V-8 engine, whose development appears as a substantial cluster of innovations in Exhibit IV, was produced without substantial alterations for 18 years.

In 1869 Louis Burger was retained to make substantial alterations to the building and he may have been the original architect.

By appropriate migrations of biochromes, an animal can achieve substantial alterations in colour or shade for varying periods of time.

Prospective purchasers who are said to include the club and restaurant tycoon Richard Caring, are thought to be keen to either demolish the building and rebuild it as a hotel or apartments or make substantial alterations to the existing structure.