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Suboptimal timing or level of the ectopically expressed Ascl1b expression might explain the lower efficiency.
However, the preclinical data and the absence of a peak in circulating caspase-cleaved CK18 in trial patients suggest suboptimal timing of blood sampling, which will need refinement in future trials incorporating obatoclax.
EDCs may disrupt the hormonal regulation and thus lead to suboptimal timing of the fasting period.
Exposure to EDCs could disrupt the endocrine systems and mechanisms that regulate these events, thereby leading to suboptimal timing in relation to the season.
First, in a subset of patients, there is a disturbance in coordination of atrial and ventricular activation with suboptimal timing of atrial contraction (AV dyssynchrony).
Since hereditary defects for these analytes are individually uncommon even in patients with thrombosis, results suggesting abnormalities of multiple analytes on the same specimen would likewise be evidence for suboptimal timing.
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It has been previously published by Mullens et al. that among the different reasons of non-response, suboptimal AV timing accounts for CRT suboptimal response in a significant proportion of patients.
114 115 Light deficiency, whether due to improper timing, suboptimal spectrum or insufficient intensity, may contribute to medical conditions commonly assumed to be age-related inevitabilities.
In this case, the effect on subsequent transmission would be negligible and the proposed 12% recommendation would be an underestimate because of suboptimal antiviral treatment timing.
The high value of RF for warfarin indicates that the likelihood of patients with suboptimal adherence (comprising timing variability, random missed doses, and random drug holidays) successfully attaining the target was 0.78 times of those with perfect adherence.
This process is analogous to that of a poorly timed automotive engine; each piston continues to burn fuel, but when timing is suboptimal, there is reduced effective engine power, wasted work and lower fuel economy [ 31].
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