To ensure the best outcome for the patient, it is important that use of the available therapies is optimized over the course of disease progression; suboptimal dosing of ChEI therapy may be associated with a reduced chance of response [ 1].
Suboptimal adherence can lead to disease progression [ 6], increasing the burden on the healthcare system due to GP and specialist appointments and hospitalisations as well as increased morbidity and mortality [ 7].
Thus, STAT3 inhibition, even if suboptimal, would slow tumour progression.
The majority described the current methods that are used to monitor CVD progression as suboptimal.
Nutrition and immunity are linked, with impaired immune function from suboptimal nutrition status hastening progression of HIV [ 1].
In a variety of disease states, adherence to treatment, defined as taking medication at the prescribed dose and schedule, is important because poor adherence results in suboptimal outcomes including disease progression, the development of resistance, greater disability, acute and more intense relapses, and premature death.
The reason for discontinuation or change of the treatment in four patients after eight cycles of CHOP was suboptimal treatment response or disease progression.
Moreover, we included subjects with complete information one to two years following the procedure, as patients are followed closely by their surgeons during this period, and the rehabilitation process can easily be altered if the progression is judged suboptimal.
6 It is interesting that three VF tests annually, the number which may be required to detect 'rapidly' progressing patients and is consistent with the number recommended by NICE for patients with suboptimal IOP and evidence of progression, was seen as impractical by many UK ophthalmologists with a specialist interest in glaucoma in terms of availability of hospital resources.
Suboptimal vitamin D status (25(OH D <75 nmol/L) is associated with the development and progression of both diabetes and chronic kidney disease (CKD) [ 1].
Suboptimal adherence to cART is strongly related to viral proliferation [ 6, 7], drug resistance [ 7, 8], disease progression [ 9], and death [ 3].
