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With jockey Tittia sitting atop Morosita Prima, and strong trial performances already under their belts, who can stand in their way? .
This analysis draws on data collected from a methodologically strong trial, uses an appropriate method for assessing cost-effectiveness, captures the role of uncertainty among model parameters, and presents the results in a format suitable for interpretation by decision makers.
Foy et al. investigated in a meta-analysis the impact of interventions on patient recruitment and concluded that organisational characteristics (e. g. strong trial infrastructure) seemed to be important [ 16].
The primary objectives of the Health Enhancing Strength Training in Nonagenarians (STRONG) trial is to assess the effectiveness of an 8-week aerobic and strength training program for improving muscle strength, daily functional capacity and quality of life (QOL) in nonagenarians.
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A subset of these regions demonstrated a linear pattern of increased responding from safe to medium to strong trials, including the bilateral insula, ACC, and inferior frontal gyrus.
These responses were modulated by individual differences in neuroticism, such that those high in neuroticism showed exaggerated anxiety experience across the entire task, and reduced brain activation from medium to strong trials in a subset of brain regions.
However, evidence is limited as there have been few large methodological strong trials.
10 There are still relatively few methodologically strong trials aimed at the primary prevention of weight gain in older children, thus indicating a need to strengthen the evidence base.
Randomized controlled trials start at the 'high' quality level of evidence, but can be 'down-graded' to 'moderate' quality, if they do not fulfil certain characteristics of strong trials, such as limitations in study design or execution, or inconsistency of results.
In what looks the strongest trial, it is surely significant that the stable that won four others last week – two at Chester, one apiece at Lingfield and Leopardstown – should have reserved Indian Chief (2.45) as its final card.
The results of the two stronger trials were published in March 2009 in The New England Journal of Medicine.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com