Sentence examples for Strong the rationale from inspiring English sources

In more heavily morbid patients, ablation under moderate sedation may be preferable to GA. Consensus level: strong The rationale for this approach is that ablation is often successful in treating small tumours without the need for resection but should ablation be unsuccessful, resection is still feasible.

Although the strongest rationale for the use of the trimodality therapy stems from the promising results of clinical phase II data, upfront systemic chemotherapy offers several practical as well as theoretical advantages (Pisters et al, 2000).

The strong rationale behind this approach is that the shape of the P-V curve at ZEEP may differ substantially depending on whether it is measured after a period of ZEEP ventilation or immediately after removal of PEEP [ 5].

Despite the strong rationale around IGF-1R pathway inhibition, the promising preclinical data and its reasonable tolerability, the clinical efficacy has been disappointing [ 49, 50].

The authors offer the hope that new-targeted therapies will be developed and describe the strong rationale for combining these agents with pre-existing ones (e.g. hsp90 inhibitors with bortezomib).

Despite the strong rationale and push for educational reforms, for most African institutions there has been little strategic effort yielding a slow and disjointed process [ 4].

The strong rationale for PID gene therapy has been strengthened further by technological advancements in the design and manufacture of clinical grade GMP-quality vectors coupled with enhanced transduction protocols and improved transplantation regimens.

In spite of the strong rationale for a role of genetic variants in Osterix influencing bone mass acquisition, we are not aware of any previous genetic studies in humans highlighting this association.

Given potential undetected safety problems and the strong rationale for risk-stratified analysis, we also feel that post hoc risk-stratified analyses should be conducted on previously completed clinical trails when such analyses are feasible.

Despite the fact that only a subset of patients with osteosarcoma are sensitive to IGF-1R inhibition, the strong preclinical rationale deserves further clinical and translational exploration.

"Initially, the complex had a strong economic rationale," said James W. Hughes, the dean of the Edward J. Bloustein School of Planning and Public Policy at Rutgers University.