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A series of structure based drug design hypotheses and focused screening efforts led to the identification of tetrahydropyrrolo-diazepenones with striking potency against ERK2 kinase.
N3 N3 dimer 25i displayed striking potency against leukemia, CNS cancer, melanoma and prostate cancer cell lines with GI50 values<0.01 μM against all the cell lines and showed the highest overall potency of the agents examined (GMG=0.0120 μM).
Similar(58)
But this year's efforts are striking for the potency of the grass-roots movement that Democrats are trying to use to their advantage — that is, the Tea Party — and for the sometimes brazen nature of the attempts.
The move to strike high-potency opioids from the public drug benefit plan is the latest attempt by Ontario to get a grip on opioid-related overdoses and overdose deaths, which have skyrocketed in recent years.
However, timing matters a great deal for general strikes' electoral potency.
I had not grown up listening to his music, but I was struck then by the potency of his lyrics, whether when engaging with zeitgeists or getting at more-basic existential issues.
Very striking.
Striking similarities.
These differences are striking.
This difference is striking.
Such improvement is striking.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com