The LGN receives inputs from neurons just a couple of steps downstream from the photoreceptors in the retina.
According to our model, this places the CFU-GEMM, 5 to 8 steps downstream from the active HSC.
Figure 4 illustrates a sample query type 1 for reaction queries: " Find reactions within at most 4 steps downstream from vPGI[Glucose-phosphate isomerase] in Bakker2001_Glycolysis".
PAINT curators chose to propagate fewer annotations that those transferred by Compara, especially those thought to be several steps downstream from the known molecular function, such as 'negative regulation of neuron apoptosis and spermatogenesis'.
In this respect, the site of cofactor action will be several steps downstream from the site of cofactor binding, and the cofactor may act in either a " cis" or " trans" mode.
These data provide further evidence that the inhibition of ISGU by 3T3-L1 adipocytexposedsed to iAsIII and MAsIII is due to the inhibition of the PDK-1 catalyzed PDK-1 catalyzedKB/activationat neither iAsIII nof MAsIII disruPKB/Aktnandthatsductioneither downstream from PDK-1/PKB/Akt, or events associAsIIIwith GLUT4 tranorocation to the plasMAsIIIbrane.
The ovaries in Hr39 and lz mutant females contain a full complement of mature oocytes, however, both lay significantly fewer eggs than controls, indicating that secretory products are required for one or more steps downstream from oocyte completion, such as ovulation, mating, sperm storage, fertilization, or egg laying.
Arsenite and MMAIII inhibit PDK-catalyzed phosphorylation of AKT in the insulin signaling cascade; DMAIII inhibits GLUT4 translocation by interfering with the signaling step(s) downstream from AKT (Paul et al. 2007a; Walton et al. 2004).
Query 1. Find reactions (and their kinetic equations if exist) that are n-step downstream or upstream from the reaction of a given model.
The key pathogenic step may be downstream from protein sequestration by the expansion, such as export of the repeat expansion to enable repeat associated non-ATG translation or an accumulation of aberrant splicing events.
