Starting from two previously identified chalcone-based FXR antagonists, we tried to increase the activity through the design and synthesis of a library containing chalcones, flavones and chromenes, based on substitution manipulation and conformation (ring closure) restriction strategy.
Starting from two previously studied muscarinic full agonists, characterized by a 1,3-dioxolane −1) and a 1,3-oxathiolane −2) cycle, two new series of muscarinic ligands were designed, obtained by the steric complication of the parent compounds produced by freezing the aminoalkyl chain into a pyrrolidine ring.
Starting from two commercial clothes mainly constituted by woven PA6 fibers, single polymer composites (SPCs) involving 24, 30 and 36 layers of each fabric were prepared and investigated taking compression molded plates based on a commercial neat PA6 grade as the reference material.
Starting from two readily available compounds, 4- 3- tert-butyl -1,2,4-oxadiazol-5-yl)aniline (1) and 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)ethanamine (10), other bioactive moieties were incorporated (such as pyrazole, pyrazolo[3,4- 3- tert-butyl -1,2,4-oxadiazol-5-yle lipophilicity of the molecules, so that the transport of the bioactive units though the cell wall barrier could be improved.
Starting from two theatre performances that position their audiences in ways that self-consciously destabilize habitual modes of perceiving (Dries Verhoeven's Funerals and Alexandra Broeder's NATURE or NURTURE), the essay demonstrates the potential of an enactive approach for understanding the political and ethical implications of theatre.
Starting from two graph classes, ordinary rooted trees and so-called generalized trees [46], [47], we show that our entropy measure captures important structural information meaningfully.
Starting from two micrograms of total RNA, gene expression analysis was performed using Genome U133 Plus 2.0 Arrays according to the GeneChip Expression Analysis Technical Manual (Rev. 5, Affymetrix Inc., Santa Clara, CA).
Starting from two very basic hypotheses and the renewal assumption, we derive a model reproducing the behavior outlined above.
For protein GB3 we ran three different simulations: i) MD starting from the native state at T = 330 K for 10 ns, ii) MD starting from two selected structures (blue circle in Fig. 1-D) at 330 K for 1ns, iii) BE of 20 ns at 400 K.
Starting from two-phase flow momentum equations an expression for the segregating particle velocities has been derived.
Here we summarize recent work that addresses these challenges at multiple scales, starting from two-species natural and synthetic ecology models, up to biosphere-level approaches.
