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Standardized timing of specimen collections may also minimize the inherent variability of test results for individual patients, thereby facilitating interpretation of serial results.
Although we could not confirm that all times in the database were recorded with standardized timing methods, the proportion of EMS teams practicing daily clock synchronization increased from 39% in December 2005 to 43% in July 2007 [ 11].
Despite these limitations, our study was stringent with respect to the standardized timing of sample collection and dietary intake (i.e., serum after a 12-h fast) as well as correlation with liver histological analysis.
IITQ responses were obtained during regularly scheduled visits, with standardized timing and conditions of administration.
Our next study will evaluate the effectiveness of this early, standardized timing of school closure in Japan.
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The order of the milestones is very unlikely to differ, since one cannot have three regions affected before two regions, and interventions such as non-invasive ventilation or gastrostomy tend to occur towards the end of life, but the study should be repeated in an incident cohort to explore cohort effects, if any, on the standardized timings.
To address the following clinical questions: For women with cesarean births, does the use of a standardized antibiotic and timing reduce the incidence of postoperative infection?
In efficacy trials, interventions are delivered in a highly standardized way, including timing and dosage of medications and perhaps even the associated patient education.
Some countries have developed local guidelines or consensus recommendations (for example, the recently published consensus recommendations on off-label use of rFVIIa by a US panel [ 71]), but European Union-wide standardized guidance (appropriate dose, timing of treatment, appropriate patients) is clearly needed.
Furthermore, studies investigated the tests in different patient populations and various settings, employing different treatment methods, and using a broad range of definitions of tests and a great variation in definitions of outcome that were often measured in non-standardized ways and with different timing of follow-ups.
A review of the use of rFVIIa to reverse anticoagulant therapy was recently published [ 29]; however, data on the timing of treatment and standardized dosing are lacking.
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