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Sound trial design also begins with a rational definition of trial arms and the expectations of what the trial is aiming to achieve.
The core tool Design-a-Trial (Datool Design-a-Trialntool Design-a-Triale DaT critiquesientifically andatahically sound trial.
Conventionally, RCTs can be distinguished by many elements that follow the well-documented principles of sound trial design [ 45].
Lastly, methodological quality varies greatly across previous exercise trials, for example in the Cochrane review [ 15] the least sound trial attended to none of the nine methodological criteria while the best attended to seven of the nine.
On each sound trial, the subject was asked: 'Are the sounds made by the same thing or different things?' On each picture trial the subject was asked: 'Are the pictures part of the same thing or different things?' Linear regression models were used to relate scores for each test (general neuropsychological and experimental) to group membership (PNFA, semantic dementia or healthy control).
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The main aim of DaT is to help trial designers with limited statistical and research experience to design scientifically and ethically sound trials.
Figure 2 shows the RT distributions for sound and no sound trials.
In addition to the cross-modal classification, uni-modal classification was performed by classifying the data from the sound trials alone.
Additionally, rumbles produced during bee sound trials exhibited an upward shift in the second formant location, compared to both white noise (p = 0.013) and control rumbles (p = 0.018) (Figure 4).
We conducted acoustic measurements on rumbles occurring during the pre-stimulus phases of all trials (n = 13), during the stimulus and post-stimulus phases of bee sound trials (n = 20), and during stimulus and post-stimulus phases of white noise trials (n = 20; see Materials and Methods).
Tukey's Honestly Significant Difference pair-wise tests revealed that rumbles produced during white noise and bee sound trials both exhibited increased fundamental frequency and fundamental frequency range, compared to pre-stimulus control rumbles (Fo: white noise vs. control p = 0.009, bee vs. control p = 0.036; Fo range: white noise vs. control p = 0.020, bee vs. control p<0.001) (Figure 4).
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