Smaller population size, no deviation from recommended appropriate comparative therapy and the incorporation of HRQoL-data were associated with a lower discount on the price at launch.
Smaller population size decreases the efficiency of purifying selection, allowing the fixation of insertions that otherwise would have been eliminated in a population with a large effective size.
After all, a bigger percentage increase is more likely when starting from a smaller population size.
Our research also favors a high income, smaller population size and denser city for lower CO2 emissions.
Although a familiar and well-known species on the Pacific Coast, the Western Gull is limited in distribution and has a smaller population size than most other North American gulls, with a total population of only about 40,000 pairs nesting at fewer than 200 colony sites.
So although it's a smaller population size than the United States, the challenge for such a small population in the foundation of the Republic to build a comprehensive energy structure in a country the size of England to serve every community, every town, every farm, every valley, every fishing community, is monumental, comparatively speaking.
The low marker density of one in every 3 MB and a smaller population size of 75 lines used in this study might have impacted the identification of new QTLs.
This difference can be explained by a smaller population size (Additional file 1: Table S2) in combination with a more unbalanced factorial mating design (Additional file 1: Figure S4) for segment SS than LS and MM.
The researchers were able to confirm that the genetic changes over time were not random but presumably driven by a selective force: the X chromosome proved to be more stable than chromosome III, for example, despite its far smaller population size (each pair of flies carries a total of four copies of chromosome III but only a single X chromosome).
Whatever the cause, large mammals are generally more vulnerable than smaller ones due to their smaller population size and low reproduction rates.
As pointed out by MacDonald and Kreitman, an excess of non-synonymous fixed differences between species may result from a much smaller population size in the past [21].
