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We conclude that delayed enhancement of GABAergic neurotransmission directly at the site of vulnerability following an ischemic event protects the vulnerable neurons from death.
Kong, R. et al. Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.
Zhao, X. et al. Immunization-elicited broadly protective antibody reveals ebolavirus fusion loop as a site of vulnerability.
This site of vulnerability is shielded by the descending β17 β18 loop of the glycan cap, removal of which potentiates ADI-15946 activity.
This is consistent with preclinical models that implicate the mPFC as a key site of vulnerability to the noxious effects of uncontrollable stressors.
Thus, light chain accommodation of the glycan shield should be taken into account in vaccine design targeting this conserved site of vulnerability.
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remove key glycans to unmask sites of vulnerability and enable the induction of neutralizing antibodies.
Wec, A. Z. et al. Antibodies from a human survivor define sites of vulnerability for broad protection against ebolaviruses.
A high-resolution definition of sites of vulnerability on Pfs25 would enable the structure-guided design of immunogens that might increase the immunogenicity of potent epitopes.
In order to counteract HIV-1 and influenza viral diversity, broadly neutralizing antibodies precisely target specific sites of vulnerability and require high levels of affinity maturation.
Recent structural and functional studies of the HIV-1 surface envelope glycoprotein gp120 have revealed sites of vulnerability that can be targeted by small molecule and peptide inhibitors, thereby inhibiting HIV-1 infection.
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