The nine-subunit core of the eukaryotic exosome shares a similar barrel-like architecture with prokaryotic complexes, but is catalytically inert.
Although the two complexes act on different substrates and are composed of different subunits, they share a similar barrel-like architecture that appears to have evolved to restrict substrate access and prevent indiscriminate degradation.
The symmetry mismatch is an absolute feature of this large energy-dependent protease and also of the proteasome, which shares a similar barrel-shaped architecture, but how it is accommodated within the complex has yet to be understood, despite recent structural investigations, due in part to the conformational lability of the N-termini.
Similar barrels, investigators say, have been found at the Kansas home of Terry Nichols, an associate of Mr. McVeigh who is being held as a material witness.
By contrast, similar barrels at LANL are stored in a refrigerated facility with filters to safeguard against bursts and environmental releases.
The pattern of Smc1(M665R -GFP fluorescence resembles that of wild-type; that is, it has a similar barrel-like structure, confirming that the mutant complexes do indeed associate with centromeric chromatin.
Plantation Rum is doing something similar with barrel finishing, but in their case, the rums, like the Barbados 2001 Vintage ($44.99), are shipped to France for their final aging in former Cognac casks.
Thornton Wilder's Our Town has a similar cracker-barrel wisdom as Keillor's and a similar quizzical narrator.
In addition, this knowledge would provide insight into structure-function relationships under poly-extreme conditions that may be generally applicable to other proteins possessing similar TIM-barrel structures.
Therefore, we can assume that the catalytic domain of the GH97 family proteins also has a similar 8-barrel fold.
