Intervention-free survival differed significantly between uncomplicated (84.8% and 62.7% at 1 and 5 years, respectively) and complicated (66.6% and 44.3% at 1 and 5 years, respectively) presentations (P<0.0001; Figure 2).
In addition, the MEDAL (Multinational Etoricoxib and Diclofenac Arthritis Long-term) [ 38] study demonstrated that individuals who received etoricoxib had significantly fewer uncomplicated gastrointestinal events than those who received diclofenac.
Notably, the "dually" deficient group was significantly protected from uncomplicated malaria.
As before, males defined as deficient by genotype and enzyme activity did not appear significantly protected from uncomplicated malaria (RR 0.84, 95% CI 0.52 1.32).
We found that G6PD-deficient females were significantly protected against uncomplicated malaria, but this protection was only seen when G6PD deficiency is described using enzyme activity.
We found that G6PD-deficient females, but not males, were significantly protected against uncomplicated malaria, but this protection was only seen when G6PD deficiency was described using enzyme activity.
Obesity was significantly associated with uncomplicated sepsis; however, this association was not present with severe sepsis.
Preterm birth and labour induction, which we found to be significantly associated with uncomplicated sepsis and severe sepsis, respectively, have also been previously cited.
All variables significantly associated with uncomplicated pregnancy in the development dataset are shown; some variables lost significance in the local replication and external confirmation datasets.
Rijzewijk et al. (33) showed that intramyocardial fat content, as detected by H-MRS, wasignificantlyly higher in uncomplicated type 2 diabetic men than in nondiabetic control subjects and was associated with impaired LV diastolic function as detected by cardiac MRI.
Using H-MRS, Rijzewijk et al. showed that the intramyocardial fat content was significantly higher in uncomplicated type 2 diabetic men than in nondiabetic controls and was related to impaired cardiac metabolism [ 49].
