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Significant variants were for the most part candidates in cancer-related genes as is shown in Table 1.
Significant variants were selected based on two criteria, allele frequency between two genotypes >0.8, and number of tags aligned to the reference >5.
Clinically significant variants and variants of uncertain clinical significance were associated with higher and slightly higher rates of management recommendations, respectively, compared with benign/no variants (RR=1.34; 95% CI (1.22 1.47); RR=1.23; 95% CI (1.09 1.38)).
Besides considering the most significant variants, we also tried to relax the significance threshold, allowing more markers to be fitted.
There will be a full textual apparatus listing all significant variants.
But no significant variants of the Penn Station plan survive, just the familiar monumental four-sided colonnade.
The applications of this technology for high throughput genomic analysis, database updating, reporting clinically significant variants, and diagnostic imaging purposes are explored using case studies.
To test the hypothesis that some functionally significant variants in the gene encoding member A3 of the ATP Binding Cassette family (ABCA3) are not detected using exon-based sequencing approaches.
While statistical adjustments are essential to refine the list of potential associations with each disease, valuable information can be extracted by the systematic collection of moderately significant variants present in more than one trait.
There are significant variants of each of these.
We will describe the embryology and importance of the most clinically significant variants.
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CEO of Professional Science Editing for Scientists @ prosciediting.com